Science Overview
Clinical Research on AndoSan
Clinical research has been conducted with several of Norway's leading research institutions on AndoSan: Oslo University Hospital (OUS), Norwegian Institute of Public Health, Pharmaceutical institute (NIPH), and Norwegian University of Life Sciences and Technology (NMBU). These studies have clearly indicated that AndoSan has immunomodulating effects. Studies have explored potential applications in cancer treatment, treatment of chronic inflammations such as IBD, and alleviating allergy and asthma symptoms. A U.S. patent concerning the use of AndoSan to inhibit the activity of cancer-promoting enzyme legumain was granted in 2020.
Human Clinical Studies
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Hetland G, Biedron R, Hetland A, Badmaev V. Andosan™: An optimal biological response modifier and health-promoting ingredient prepared from Agaricus blazei mushroom. Nova Science Pub Inc. New York 2014, pp 1-71. ISBN: 978-1-63117-130- 7. –Note: This book contains a semi-quantitative survey after 3 months’ intake in 2012 of Andosan in professional swimmers in Ann Arbor, MI, USA.
Preclinical Studies (in Vivo & In Vitro Data)
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Vivacell Biotechnology. Studies in a cell assay model of SARS-CoV-2 revealed that AndoSan, at increasing concentrations, reduced the binding of SARS-CoV-2 spike proteins (Unique for the SARS virus) to ACE2 receptors by up to 40%. 2022, unpublished results.
Biocompatibility Data
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For all clinical studies– in healthy volunteers, IBD patients, multiple myeloma patients, blood donors with pollen allergy, and asthma, there were no serious side effects. The treatment period was 60 ml/day for two weeks in healthy volunteers, for three weeks in IBD patients, and seven weeks in multiple myeloma patients, and two months in allergics.
Other Publications
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Pernille Karppinen: Master thesis 2013 at Pharmaceutical Institute, University of Oslo/ Norwegian University of Life Sciences Institutt for kjemi, bioteknologi og matvitenskap: Search for biologically active compounds in AndoSan™, a medicinal mushroom extract PMC3168293.
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G. Hetland G. Agaricus bM mushroom may protect athletes against inflammation, infection, and asthma. Ch 17, In Mushrooms: Types, Properties, and Nutrition. Eds: S Andres and N Baumann. 2012. Nova Science Pub Inc. ISBN 987-1-61470-110-1 Biedron R, Tangen JM, Maresz K, Hetland G. Agaricus blazei Murill – immunomodulatory properties and health benefits. Review. Funct Foods Health Dis 2012, 2(11):428-47.